AG Pflugfelder Publikationen

Carmelo Quarta, Alexandre Fisette, Yanjun Xu, Gustav Colldén, Beata Legutko, Yu-Ting Tseng, Alexander Reim, Michael Wierer, Maria Caterina De Rosa, Valentina Klaus, Rick Rausch, Vidhu Thaker, Elisabeth Graf, Tim Strom, Anne-Laurie Poher, Tim Gruber, Ophélia Le Thuc, Alberto Cebrian-Serrano, Dhiraj Kabra, Luigi Bellocchio, Stephen Woods, Gert Pflugfelder, Ruben Nogueiras, Lori Zeltser, Ilona Grunwald Kadow, Anne Moon, Cristina García-Cáceres, Matthias Mann, Mathias Treier, Claudia Doege, and Matthias Tschoep (2019)
"Functional identity of hypothalamic melanocortin neurons depends on Tbx3."
Nature Metabolism DOI: 10.1038/s42255-018-0028-1

Reinhardt S, Schuck F, Stoye N, Hartmann T, Grimm MOW, Pflugfelder G, Endres K. (2019)
"Transcriptional repression of the ectodomain sheddase ADAM10 by TBX2 and potential implication for Alzheimer's disease."
Cellular and molecular life sciences : CMLS. doi: 10.1007/s00018-018-2998-2

Pflugfelder, G. O., Eichinger, F and Shen, J. (2017)
"T-box genes in Drosophila limb development."
Curr. Topics in Dev. Biol. 122: 313-354.

Liu, S., Sun, J., Wang, D., Pflugfelder, G.O., Shen, J. (2016)
"Fold formation at the compartment boundary of Drosophila wing requires Yki signaling to suppress JNK dependent apoptosis"
Scientific Reports 6: 38003, doi: 10.1038/srep38003

Fischer, K and Pflugfelder, G.O. (2015)
"Putative breast cancer driver mutations in TBX3 cause impaired transcriptional repression."
Frontiers in Oncology 5:244, doi: 10.3389/fonc.2015.00244

Tsai YC, Grimm S, Chao JL, Wang SC, Hofmeyer K, Shen J, Eichinger F, Michalopoulou T, Yao CK, Chang CH, Lin SH, Sun YH, Pflugfelder GO. (2015)
"Optomotor-blind negatively regulates Drosophila eye development by blocking Jak/STAT signaling."
PLoS One. 10(3), e0120236

Shen, J., J. Lu, D. Wang, M. Yin, I. Hoffmann, A. Legler and G. Pflugfelder (2014).
"The orthologous Tbx transcription factors Omb and TBX2 induce epithelial cell migration and extrusion in vivo without involvement of matrix metalloproteinases "
Oncotarget, 5
(23), 11998-12015

Sen, A., Grimm, S., Hofmeyer, K., and Pflugfelder, G.O. (2014)
Optomotor-blind in the development of the Drosophila HS and VS lobula plate tangential cells
J. Neurogenetics 28, 250-263.

Zhang, X., D. Luo, G. O. Pflugfelder and J. Shen (2013).
"Dpp signaling inhibits proliferation in the Drosophila wing by Omb-dependent control of bantam in a region specific manner."
Development 140, 2917-2922.

Schneider, M., Scheffer, K., Bund, T., Boukhallouk, F., Lambert, C., Cotarelo, C., Pflugfelder, G., Florin, F. and Spoden, G. (2013)
The Transcription Factors TBX2 and TBX3 interact with HPV16 L2 and repress the Long Control Region of Human Papillomaviruses
J. Virol. 87, 4461-4477

Mayer, L.R., Diegelmann, S., Abassi, Y., Eichinger, F., and Pflugfelder, G.O. (2013)
Enhancer trap infidelity in Drosophila optomotor-blind
Fly 7, 1-11

Sui, L., Pflugfelder, G. O. and Shen, J. (2012).
The Dorsocross T-box transcription factors promote tissue morphogenesis in the Drosophila wing imaginal disc
Development, 139, 2773 - 2782

Shen, J., Dahmann, C. and Pflugfelder, G. O. (2010).
Spatial discontinuity of optomotor-blind expression in the Drosophila wing imaginal disc disrupts epithelial architecture and promotes cell sorting.
BMC Dev Biol 10, 23.

Sen, A., Gadomski, C., Balles, J., Abassi, Y., Dorner, C. and Pflugfelder, G. O. (2010).
Null mutations in Drosophila Optomotor-blind affect T-domain residues conserved in all Tbx proteins.
Mol Genet Genomics 283, 147-156.

Pflugfelder, G.O. (2009)
omb and circumstance
J. Neurogenetics 23, 15-33

Kretzschmar, D and Pflugfelder, G.O. (2009)
Neurodegeneration. Invertebratenmodelle für die Erforschung menschlicher neurodegenerativer Erkrankungen (no peer review)
BIOforum 32 (5), 36-38.

Yin, M., Shen, J., Pflugfelder, G.O. and Müllen. K. (2008)
A Fluorescent Core-shell Dendritic Macromolecule Specifically Stains The Extracellular Matrix
J Am Chem Soc. 130, 7806-7807

Yin, M., Shen, J., Gropeanu, R., Pflugfelder, G.O., Weil, T. and Müllen. K. (2008)
Fluorescent Core-shell Nanoparticle for Specific Cell Nucleus Staining
Small 4, 894-898

Shen, J., Dorner, C., Bahlo, A., and Pflugfelder, G.O. (2008)
optomotor-blind suppresses instability at the A/P compartment boundary of the Drosophila wing
Mech. Dev. 125, 233-246

Hofmeyer, K.D., Kretzschmar, D. and Pflugfelder G.O. (2008)
optomotor-blind expression in glial cells is required for correct axonal projection across the Drosophila inner optic chiasm
Dev. Biol. 315, 28-41.

Ryder, E., Ashburner, M., Bautista-Llacer, R., Drummond, J., Webster, J., Johnson, G., Morley, T., Chan, S., Blows, F., Coulson, D., Reuter, G., Baisch, H., Apelt, C., Kauk, A., Rudolph, T., Kube, M., Klimm, M., Nickel, C., Szidonya, J., Maroy, P., Pal, M., Rasmuson-Lestander, A., Ekstrom, K., Stocker, H., Hugentobler, C., Hafen, E., Gubb, D., Pflugfelder, G., Dorner, C., Mechler, B., Schenkel, H., Marhold, J., Serras, F., Corominas, M., Punset, A., Roote, J., Russell, S. (2007).
The DrosDel Deletion Collection: A Drosophila Genome-Wide Chromosomal Deficiency Resource.
Genetics 177, 615-629

Porsch M., Sauer, M. Schulze S., Bahlo A., Roth M., and Pflugfelder G.O. (2005)
The relative role of the T-domain and flanking sequences for developmental control and transcriptional regulation in protein chimeras of Drosophila OMB and ORG-1
Mech. Dev. 122, 81-96

Kretzschmar D., Tschäpe J., Bettencourt da Cruz A., Asan E., Poeck B., Strauss R., and Pflugfelder G.O. (2005)
Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila
Glia 49, 59-72

Ryder, E., Blows, F., Ashburner, M., Bautista-Llacer, R., Coulson, D., Drummond, J., Webster, J., Gubb, D., Gunton, N., Johnson, G., O'Kane, C. J., Huen, D., Sharma, P., Asztalos, Z., Baisch, H., Schulze, J., Kube, M., Kittlaus, K., Reuter, G., Maroy, P., Szidonya, J., Rasmuson-Lestander, A., Ekstrom, K., Dickson, B., Hugentobler, C., Stocker, H., Hafen, E., Lepesant, J. A., Pflugfelder, G., Heisenberg, M., Mechler, B., Serras, F., Corominas, M., Schneuwly, S., Preat, T., Roote, J., Russel, S. (2004)

The DrosDel collection: a set of P-element insertions for generating custom chromosomal aberrations in Drosophila melanogaster.
Genetics 167, 797-813

Kretzschmar, D. and Pflugfelder, G.O. (2002)
Glia in development, function, and neurodegeneration of the adult insect brain
Brain Research Bulletin 57, 121-131

Kretzschmar D., Poeck B., Roth H., Ernst R., Keller A., Porsch M., Strauss R., and Pflugfelder G.O. (2000)
Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP-3 adaptin gene ruby
Genetics 155, 213-223

Pflugfelder G.O. (1999)
Structure-function analysis of the Drosophila optic lobes
in Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. W.E. Crusio and R.T. Gerlai, eds., Elsevier, Amsterdam, 512-536

Eberle K.K., Zinsmaier K. E., Buchner S., Gruhn M., Jenni M., Arnold C., Leibold C., Reisch D., Walter N., Hafen E., Hofbauer A., Pflugfelder G.O., and Buchner E. (1998)
Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis
Cell Tissue Res. 294, 203-217

Pflugfelder G.O. (1998)
Genetic lesions in Drosophila behavioural mutants
Behavioural Brain Research 95, 3-15

Porsch M., Hofmeyer K., Bausenwein B.S., Grimm S., Weber B., Miassod R., and Pflugfelder G.O. (1998)
Isolation of a Drosophila T-box gene closely related to human TBX1
Gene 212, 237-248

Tsai S.-F., Jang C.-c., Prikhod´ko G. G., Bessarab D. A., Tang C.-Y., Pflugfelder G. O. and Sun Y. H. (1997)
Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila
Proc. Natl. Acad. Sci. USA 94, 3837-3841

Klagges B.R.E., Heimbeck G., Godenschwege T., Hofbauer A., Pflugfelder G.O., Reifegerste R., Reisch D., Schaupp M., Buchner S. and Buchner E. (1996)
Invertebrate synapsins: a single gene codes for several isoforms in Drosophila
J. Neuroscience 16, 3154-3165

Grimm S. and Pflugfelder G. (1996)
Control of the gene optomotor-blind in Drosophila wing development by decapentaplegic and wingless
Science 271, 1601-1603

Pflugfelder G.O. and Heisenberg M. (1995)
optomotor-blind of Drosophila melanogaster: A neurogenetic approach to optic lobe development and optomotor behaviour.
Comparative Biochemistry and Physiology 110A, 185-202

Reichmuth C., Becker S., Benz M., Debel K., Reisch D., Heimbeck G., Hofbauer A., Klagges B., Pflugfelder G.O. and Buchner E. (1995)
The sap47 gene of Drosophila melanogaster codes for a novel conserved neuronal protein associated with synaptic terminals
Mol. Brain Res. 32, 45-54

Grimm S. and Pflugfelder G.O. (1995)
Nonradioactive method for restriction mapping of Lambda phage DNA
BioTechniques 18, 400-401

Balles J. and Pflugfelder G.O. (1994)
Facilitated isolation of rare recombinants by ligase chain reaction. Selection for intragenic crossover events in the Drosophila optomotor-blind gene.
Mol. Gen. Genetics 245, 734-740

Poeck B., Hofbauer A. and Pflugfelder G.O. (1993)
Expression of the Drosophila optomotor-blind gene transcript in neuronal and glial cells of the developing nervous system.
Development 117, 1017-1029

Poeck B., Balles J. and Pflugfelder G.O. (1993)
Transcript identification in the optomotor-blind locus of Drosophila melanogaster by intragenic recombination mapping and PCR-aided sequence analysis of lethal point mutations.
Mol. Gen. Genetics 238, 325-332

Reifegerste R., Grimm S., Albert S., Lipsky N., Heimbeck G., Hofbauer A., Pflugfelder G.O., Quack D., Reichmuth C., Schug B., Zinsmaier K.E., Buchner S. and Buchner E. (1993)
An invertebrate calcium-binding protein of the calbindin subfamily: protein structure, genomic organization and expression pattern of the calbindin-32 gene of Drosophila.
J. Neuroscience 13, 2186-2198

Pflugfelder G.O., Roth H. and Poeck B. (1992)
A homology domain shared between Drosophila optomotor-blind and mouse Brachyury is involved in DNA binding
Biochem. Biophys. Res. Commun. 186, 918-925

Kretzschmar D., Brunner A., Wiersdorff V., Pflugfelder G.O., Heisenberg M. and Schneuwly S. (1992)
giant lens, a gene involved in cell determination and axon guidance in the visual system of Drosophila melanogaster.
EMBO J. 11, 2531-2539

Pflugfelder G.O., Roth H., Poeck B., Kerscher S., Schwarz H., Jonschker B. and Heisenberg M. (1992)
The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: Isolation and characterization of the gene.
Proc. Natl. Acad. Sci. USA 89, 1199-1203

Brunner A., Wolf R., Pflugfelder G.O., Poeck B. and Heisenberg M. (1992)
Mutations in the proximal region of the optomotor-blind locus of Drosophila melanogaster reveal a gradient of neuroanatomical and behavioral phenotypes.
J. Neurogenetics 8, 43-55

Reifegerste R., Faust C., Lipski N., Heimbeck G., Pflugfelder G.O., Zinsmaier K.E., Heizmann C.W., Buchner S. and Buchner E. (1991)
A novel EF-hand Ca2+ -binding protein is expressed in discrete subsets of muscle and nerve cells of Drosophila.
in: Novel Calcium-binding proteins. Springer Verlag, Berlin.

Zinsmaier K.E., Hofbauer A., Heimbeck G., Pflugfelder G.O., Buchner S. and Buchner E. (1990)
A cysteine-string protein is expressed in the retina and brain of Drosophila.
J. Neurogenetics 7, 15-29

Pflugfelder G.O., Schwarz H., Roth H., Poeck B., Sigl A., Kerscher S., Jonschker B., Pak W.L. and Heisenberg M. (1990)
Genetic and molecular characterization of the optomotor-blind gene locus in Drosophila melanogaster.
Genetics 126, 91-104

Gilmour D.S., Pflugfelder G.O., Wang J.C. and Elgin S.C.R. (1986)
Topoisomerase I interacts with transcribed regions in Drosophila cells.
Cell 44, 401-407

Buttgereit D., Pflugfelder G.O. and Grummt I. (1985)
Growth-dependent regulation of rRNA synthesis is mediated by a transcription initiation factor (TIF-IA).
Nucl. Acids Res. 13, 8165-8180

Fleischman G., Pflugfelder G.O., Steiner E.K., Javaherian K., Howard G.C., Wang J.C. and Elgin S.C.R. (1984)
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome.
Proc. Natl. Acad. Sci. USA 81, 6958-6962

Kirkegaard K., Pflugfelder G.O. and Wang, J.C. (1984)
The cleavage of DNA by type I DNA topoisomerase.
Cold Spring Harbor Symp. Quant. Biol. XLIX, 411-419

Pflugfelder G.O. and Sonnenbichler J. (1982)
Oligonucleosomes as a model system for chromatin transcription. Transcription with E. coli DNA-dependent RNA polymerase.
J. Mol. Biol. 158, 365-384

Pflugfelder G.O., Groome M., Wolf G. and Sonnenbichler, J. (1982)
Assessment of naked DNA content in oligonucleosome preparations (appendix).
J. Mol. Biol. 158, 385-389 (appendix)

Grummt I. and Pflugfelder G. (1981)
Regulatory factors involved in the transcription of mouse ribosomal genes.
in "Developmental Biology Using Purified Genes" AP; N.Y., 303-312

Pflugfelder G. and Sonnenbichler J. (1978)
A rapid purification method for DNA-dependent RNA polymerase B from rat liver.
FEBS Letters 93, 361-364